Lab Publications

 





Selected and recent publications (complete list of publications by Jacek Gaertig on Pubmed)

Hyperglutamylation of tubulin can either stabilize or destabilize microtubules in the same cell.
Wloga, D., Dave, D., Meagley, J., Rogowski, K., Jerka-Dziadosz, M., and Gaertig, J.
Eukaryotic Cell (2009): published online.

DYF-1 is required for axoneme assembly in Tetrahymena.
Dave, D., Wloga, D., Sharma, S., and Gaertig, J.
Eukaryotic Cell (2009): published online.

Evolutionary divergence of enzymatic mechanisms for post-translational 
polyglycylation.
Rogowski, K., Juge, F., van Dijk, J., Wloga, D., Strub, J.-M., Leviliers, N., Thomas, D., Bre, M.-H., 
Van Dorseelaer, A., Gaertig, J., Janke, C.
Cell (2009), 137: 1076-1087.

TTLL3 is a tubulin glycine ligase that regulates the assembly of cilia.
Wloga. D., Webster, D., Rogowski, K., Bre, M.-H., Levilliers, N., Jerka-Dziadosz, M., Janke, C.,
Dougan, S.T., and Gaertig. J.
Developmental Cell (2009), 16:867-876.

Ciliary tubulin and its post-translational modifications. In: Ciliary functions in
mammalian development.
Gaertig, J. and Wloga, D.
Current Topics in Developmental Biology (2008), 85: 83-113.

Glutamylation on alpha-tubulin is not essential but affects the assembly and
functions of a subset of microtubules in Tetrahymena.
Wloga,D., Rogowski, K., Sharma, S., vanDijk, J., Janke, C., Edde, B., Bre, M.-H., Levilliers, N., 
Redeker, V., Duan, J., Gorovsky, M.A., Jerka-Dziadosz, M.A., and Gaertig, J.
Eukaryotic Cell (2008), 7: 1362-1372.

The tubulin code.
Verhey, K.J. and Gaertig J.
Cell Cycle (2007), 6: 2152-2160.

Katanin regulates dynamics of microtubules and biogenesis of cilia.
Sharma, N., Bryant, J., Wloga, D., Donaldson, R., Davis, R.C., Jerka-Dziadosz M., and Gaertig, J.
J. Cell Biol. (2007), 178: 1065-1079.

Microtubule acetylation promotes  kinesin-1 binding and transport. 
Reed, N.A., Cai D., Blasius, T.L., Jih, G.T., Meyhofer, E., Gaertig, J., and Verhey, K.J. 
Current Biol. (2006), 16: 2166-2172.

Macronuclear Genome Sequence of the Ciliate Tetrahymena thermophila, a Model Eukaryote
Eisen J.A.  et al.
PLoS Biology. 4, e286.

Members of the Nima-related kinase family  promote disassembly of cilia by multiple mechanisms
Wloga, D., Camba, A., Rogowski, K. , G. Manning, Jerka-Dziadosz, M., and Gaertig, J
Mol. Biol. Cell.(2006)  17: 2799-2810

Tetrahymena -- the advanced eukaryote model.
Gaertig J.
The Biochemist, December 2005 download pdf

Tubulin polyglutamylase enzymes are members of the TTL domain protein family.
Janke,C., Rogowski K., Wloga,D., Regnard C., Kajava,A.V., Strub,J.M., Temurak,N., van Dijk,J., Boucher,D., van Dorseelaer A., Suryavanshi,S., Gaertig,J., Edde,B.
Science (2005) 308: 1758-1762.

Hypoxia regulates assembly of cilia in suppressors of Tetrahymena lacking an intraflagellar transport  subunit gene.
Brown, J.M., Fine. N.A., Pandiyan G., Thazhath, R. and Gaertig J.
Mol. Biol. Cell. 14: 3192-3207 (2003). 

Polyglycylation domain of beta-tubulin maintains axonemal architecture and controls progression of cytokinesis in Tetrahymena.
Thazhath R., Liu, C. and Gaertig J.
Nature Cell Biol. 4: 256-259 (2002)

Polyglycylation of tubulin is essential and affects cell motility and division in Tetrahymena thermophila
Xia L., Hai B.,Gao Y.,Burnette D.,Thazhath R., Duan Y., Bré M-H., Levilliers N.,Gorovsky  M.A.and Gaertig J.
 J. Cell Biol. 2000, 149, 1097-1106.  

Kinesin-II is preferentially targeted to assembling cilia and is required for ciliogenesis and normal cytokinesis in Tetrahymena.
Brown, J., Marsala, C, Kosoy, R., Gaertig J.
Mol. Biol. Cell. 1999, 10, 3081-3096

Surface display of a parasite antigen in the ciliate Tetrahymena thermophila.
Gaertig J, Gao Y, Tishgarten T, Clark TG, Dickerson HW
Nat Biotechnol. 1999 May;17(5):462-5.